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The 5-HT 2C receptor2 The abbreviations used are: 5-HT, 5-hydroxytryptamine; UTR, untranslated region; SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis; K d , dissociation constant; and IC 50 , concentration of competitor required to inhibit binding by 50%. The following symbols are used for degenerate bases: K for guanine (G) and uridine (U); W for adenosine...
Mesulergine displays approximately 50-fold higher affinity for the rat 5-HT 2 receptor than for the human receptor. Comparison of the deduced amino acid sequences of cDNA clones encoding the human and rat 5-HT 2 receptors reveals only 3 amino acid differences in their transmembrane domains. Only one of these differences (Ser -> Ala at position 242 of TM5) is near to regions implicated...
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