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Purpose. To study the intrinsic parameters of P-glycoprotein (P-gp) transport and drug-drug interactions at the blood-brain barrier (BBB), as few quantitative in vivo data are available. These parameters could be invaluable for comparing models and predicting the in vivo implications of in vitro studies. Methods. The brains of P-gp-deficient mice mdr1a(-/-) and wild-type mice were perfused in situ...
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