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The HIV-1-specificvpugene encodes an integral membrane phosphoprotein which affects three aspects of the HIV-1 infectious cycle: it enhances virion release from infected cells; it causes degradation of the CD4 protein in the endoplasmic reticulum; and it delays syncytia formation in HIV-1-infected CD4+T-cells. Although little is known about how Vpu mediates these effects, it has been proposed to function...
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