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Osteoporosis-related vertebral fractures represent a major public health problem. Anatomy-specific CT-based finite element (FE) simulations could help in identifying which vertebrae have the highest risk of fracture and thus help to decide upon the need for vertebroplasty or other surgical intervention. Continuum level FE simulations require effective macroscopic material properties of the vertebra...
For understanding the fracture risk of vertebral bodies the macroscopic mechanical properties of the cancellous core are of major interest. Due to the hierarchical nature of bone, these depend in turn on the micromechanical properties of bone extracellular matrix which is at least linear elastic transverse isotropic. The experimental determination of local elastic properties of bone ex vivo necessitates...
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