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Background Single-nucleotide polymorphisms (SNPs) in the IL28B and PNPLA3 gene regions have been associated with hepatic steatosis in genotype 1 (G1) chronic HCV infection but their clinical impacts remain to be determined. Aim We sought to validate these associations and to explore their impact on treatment response to peginterferon and ribavirin therapy. Methods A total of 972 G1 HCV-infected...
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