Search results for: B. Evrard

Items from 1 to 20 out of 57 results

article

Recent outbreak of chilblain‐like lesions is not directly related to SARS‐CoV‐2 infection

J. Rouanet, E. Lang, F. Beltzung, B. Evrard, more

Journal of the European Academy of Dermatology and Venereology > 34 > 11 > e689 - e692

article

Short‐term effect of outdoor mould spore exposure on prescribed allergy medication sales in Central France

D. Caillaud, M. Cheriaux, S. Martin, C. Ségala, more

Clinical & Experimental Allergy > 48 > 7 > 837 - 845

Background Outdoor moulds are classically associated with exacerbations of asthma. Objective The aim of this paper was to examine nasal allergy morbidity by studying the short‐term relationship between mould spore exposure and daily sales of reimbursable anti‐allergic treatment in central France. Methods The relationship between daily changes in mould concentrations and daily sales obtained from...

article

Peanut gastrointestinal delivery oral immunotherapy in adolescents: Results of the build‐up phase of a randomized, double‐blind, placebo‐controlled trial (PITA study)

J.‐L. Fauquert, E. Michaud, B. Pereira, L. Bernard, more

Clinical & Experimental Allergy > 48 > 7 > 862 - 874

Background Oral immunotherapy to peanut is effective in desensitizing patients but has significant side effects including anaphylaxis and gastrointestinal symptoms. In most protocols, peanut is administered in a vehicle food. Objective In an exclusively adolescent population, we tested a new approach using sealed capsules of peanut (gastrointestinal delivery oral immunotherapy or GIDOIT) to bypass...

article

An update on molecular cat allergens: Fel d 1 and what else? Chapter 1: Fel d 1, the major cat allergen

B. Bonnet, K. Messaoudi, F. Jacomet, E. Michaud, more

Allergy, Asthma & Clinical Immunology > 2018 > 14 > 1 > 1-9

Background Cats are the major source of indoor inhalant allergens after house dust mites. The global incidence of cat allergies is rising sharply, posing a major public health problem. Ten cat allergens have been identified. The major allergen responsible for symptoms is Fel d 1, a secretoglobin and not a lipocalin, making the cat a special case among mammals. Main body Given its clinical predominance,...

article

Development of an analytical method for crystalline content determination in amorphous solid dispersions produced by hot-melt extrusion using transmission Raman spectroscopy: A feasibility study

L. Netchacovitch, E. Dumont, J. Cailletaud, J. Thiry, more

International Journal of Pharmaceutics > 2017 > 530 > 1-2 > 249-255

The development of a quantitative method determining the crystalline percentage in an amorphous solid dispersion is of great interest in the pharmaceutical field. Indeed, the crystalline Active Pharmaceutical Ingredient transformation into its amorphous state is increasingly used as it enhances the solubility and bioavailability of Biopharmaceutical Classification System class II drugs. One way to...

article

Global approach for the validation of an in-line Raman spectroscopic method to determine the API content in real-time during a hot-melt extrusion process

L. Netchacovitch, J. Thiry, C. De Bleye, E. Dumont, more

Talanta > 2017 > 171 > C > 45-52

Since the Food and Drug Administration (FDA) published a guidance based on the Process Analytical Technology (PAT) approach, real-time analyses during manufacturing processes are in real expansion.In this study, in-line Raman spectroscopic analyses were performed during a Hot-Melt Extrusion (HME) process to determine the Active Pharmaceutical Ingredient (API) content in real-time. The method was validated...

article

Rôle des cellules dendritiques de la muqueuse digestive dans la tolérance orale

B. Evrard

Revue Fran�aise d�Allergologie > 2017 > 57 > 3 > 123-124

article

Oral probiotic treatment of Lactobacillus rhamnosus Lcr35^® prevents visceral hypersensitivity to a colonic inflammation and an acute psychological stress

Y. Darbaky, B. Evrard, S. Patrier, J. Falenta, more

Journal of Applied Microbiology > 122 > 1 > 188 - 200

Aims This study evaluated the efficacy of a repeated oral treatment with two active pharmaceutical ingredients (Lcr Lenio^® and Lcr Restituo^®) derivated from the probiotic bacterial strain Lactobacillus rhamnosus Lcr35^® in two animal models mimicking different features of irritable bowel syndrome (IBS). IBS is characterized by visceral pain associated with alteration of bowel transit. IBS patients...

article

L’angiopoïétine-1 : le chainon manquant dans la physiopathologie du syndrome POEMS ?

F. Coutant, Z. Tatar, P.O. Rouzaire, B. Evrard, more

Revue du Rhumatisme > 2016 > 83 > S1 > A69

article

A simple calibration approach based on film-casting for confocal Raman microscopy to support the development of a hot-melt extrusion process

L. Netchacovitch, J. Thiry, C. De Bleye, E. Dumont, more

Talanta > 2016 > 154 > C > 392-399

When developing a new formulation, the development, calibration and validation steps of analytical methods based on vibrational spectroscopy are time-consuming. For each new formulation, real samples must be produced and a “reference method” must be used in order to determine the Active Pharmaceutical Ingredient (API) content of each sample. To circumvent this issue, the paper presents a simple approach...

article

Binding Potency of Heparin Immobilized on Activated Charcoal for DNA Antibodies

E. A. Snezhkova, A. Tridon, B. Evrard, V. G. Nikolaev, more

Bulletin of Experimental Biology and Medicine > 2016 > 160 > 4 > 444-447

In vitro experiments showed that heparin adsorbed on activated charcoal can bind antibodies raised against native and single-stranded DNA in a diluted sera pool with a high level of these DNA. Thus, heparin used as anticoagulant during hemosorption procedure can demonstrate supplementary therapeutic activity resulting from its interaction with various agents involved in acute and chronic inflammatory...

article

Vibrational spectroscopy and microspectroscopy analyzing qualitatively and quantitatively pharmaceutical hot melt extrudates

L. Netchacovitch, J. Thiry, C. De Bleye, P.-F. Chavez, more

Journal of Pharmaceutical and Biomedical Analysis > 2015 > 113 > Complete > 21-33

Since the last decade, more and more Active Pharmaceutical Ingredient (API) candidates have poor water solubility inducing low bioavailability. These molecules belong to the Biopharmaceutical Classification System (BCS) classes II and IV. Thanks to Hot-Melt Extrusion (HME), it is possible to incorporate these candidates in pharmaceutical solid forms. Indeed, HME increases the solubility and the bioavailability...

article

Le dosage des IgE spécifiques d’allergène à l’heure de l’accréditation EN ISO 15189 : stratégie proposée par le réseau AllergoBioNet

A. Sarrat, C. Lambert, F. Bienvenu, S. Brabant, more

Revue Francaise d'Allergologie > 2015 > 55 > 3 > 237-238

La détection et la quantification des immunoglobulines (Ig) E spécifiques d’allergène est une étape importante du diagnostic et du suivi en allergologie. Elle est soumise actuellement, au même titre que l’ensemble des examens de biologie médicale, à l’obligation d’accréditation selon la norme internationale EN ISO 15189. Le réseau des biologistes de l’allergie AllergoBioNet propose une procédure d’accréditation...

article

A review of pharmaceutical extrusion: Critical process parameters and scaling-up

J. Thiry, F. Krier, B. Evrard

International Journal of Pharmaceutics > 2015 > 479 > 1 > 227-240

Hot melt extrusion has been a widely used process in the pharmaceutical area for three decades. In this field, it is important to optimize the formulation in order to meet specific requirements. However, the process parameters of the extruder should be as much investigated as the formulation since they have a major impact on the final product characteristics. Moreover, a design space should be defined...

article

The importance of EN ISO 15189 accreditation of allergen‐specific IgE determination for reliable in vitro allergy diagnosis

C. Lambert, A. Sarrat, F. Bienvenu, S. Brabant, more

Allergy > 70 > 2 > 180 - 186

BackgroundAllergen‐specific serum immunoglobulin E detection and quantification have become an important step in allergy diagnosis and follow‐up. In line with the current trend of laboratory test accreditation to international standards, we set out to design and assess an accreditation procedure for allergen‐specific serum IgE. MethodsMethod validation according to the accreditation procedure under...

article

Airborne pollen levels and drug consumption for seasonal allergic rhinoconjunctivitis: a 10‐year study in France

D. M. Caillaud, S. Martin, C. Ségala, P. Vidal, more

Allergy > 70 > 1 > 99 - 106

BackgroundFew time‐series studies, and none lasting longer than 4 years, have investigated the etiology of treated seasonal allergic rhinoconjunctivitis (SAR) on the basis of anti‐allergic medication prescriptions. The aim of this article was to study the short‐term relationship between pollen exposure and drug‐treated SAR over 10 years in an urban area in central France. MethodsA SAR case was defined...

article

Efficacité du rituximab dans la prise en charge du syndrome hémolytique et urémique par anticorps anti-facteur H chez l’adulte : à propos d’un cas

C. Gao, C. Garrouste, A. Lautrette, B. Evrard, more

Nephrologie & Therapeutique > 2014 > 10 > 5 > 350

Le syndrome hémolytique urémique atypique (SHUa) lié à un anticorps anti-facteur H (FH) est décrit essentiellement chez les enfants et adolescents. Moins de 10 cas sont rapportés chez l’adulte. Nous rapportons un cas traité par plasmaphérèses et rituximab.Un homme de 27ans est hospitalisé pour une insuffisance rénale aiguë. À l’admission, les examens biologiques montrent :– une microangiopathie thrombotique...

article

Exposition aux pollens et consommation de médicaments anti-allergiques pour rhinite allergique saisonnière à Clermont-Ferrand pendant 10ans

D. Caillaud, S. Martin, C. Ségala, P. Vidal, more

Revue Francaise d'Allergologie > 2014 > 54 > 3 > 233

article

Device-based controlled local delivery of anastrozol into peritoneal cavity: in vitro and in vivo evaluation

F. Krier, R. Riva, S. Defrère, M. Mestdagt, more

Journal of Drug Delivery Science and Technology > 2014 > 24 > 2 > 198-204

Local treatment using drug loaded implants allows decreasing seric concentrations of the active ingredient with the purpose of limiting side effects and reaching perfect observance. Nowadays, some diseases are already treated with implants, but generally, by subcutaneous or intra vaginal implantation. In this work, a new implant device dedicated to the intra-peritoneal cavity was developed. For this...

article

Diagnostic de l’allergie alimentaire à la noisette chez l’enfant : il faut rester prudent !

B. Evrard, E. Michaud, B. Rondet, A. Tridon, more

Revue Francaise d'Allergologie > 2013 > 53 > 1 > 53-55

Le diagnostic d’allergie alimentaire à la noisette a récemment bénéficié des dosages sériques d’IgE spécifiques vis-à-vis des fractions Cor a 1 et Cor a 8 dont la présence orienterait vers la bénignité pour la fraction Cor a 1 et la gravité pour la fraction Cor a 8. Nous rapportons quatre cas pour lesquels cette notion est contredite. Le test de provocation oral (TPO) à la noisette a provoqué des...

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INFONA - science communication portal

Search results for: B. Evrard

Recent outbreak of chilblain‐like lesions is not directly related to SARS‐CoV‐2 infection

Short‐term effect of outdoor mould spore exposure on prescribed allergy medication sales in Central France

Peanut gastrointestinal delivery oral immunotherapy in adolescents: Results of the build‐up phase of a randomized, double‐blind, placebo‐controlled trial (PITA study)

An update on molecular cat allergens: Fel d 1 and what else? Chapter 1: Fel d 1, the major cat allergen

Development of an analytical method for crystalline content determination in amorphous solid dispersions produced by hot-melt extrusion using transmission Raman spectroscopy: A feasibility study

Global approach for the validation of an in-line Raman spectroscopic method to determine the API content in real-time during a hot-melt extrusion process

Rôle des cellules dendritiques de la muqueuse digestive dans la tolérance orale

Oral probiotic treatment of Lactobacillus rhamnosus Lcr35^® prevents visceral hypersensitivity to a colonic inflammation and an acute psychological stress

L’angiopoïétine-1 : le chainon manquant dans la physiopathologie du syndrome POEMS ?

A simple calibration approach based on film-casting for confocal Raman microscopy to support the development of a hot-melt extrusion process

Binding Potency of Heparin Immobilized on Activated Charcoal for DNA Antibodies

Vibrational spectroscopy and microspectroscopy analyzing qualitatively and quantitatively pharmaceutical hot melt extrudates

Le dosage des IgE spécifiques d’allergène à l’heure de l’accréditation EN ISO 15189 : stratégie proposée par le réseau AllergoBioNet

A review of pharmaceutical extrusion: Critical process parameters and scaling-up

The importance of EN ISO 15189 accreditation of allergen‐specific IgE determination for reliable in vitro allergy diagnosis

Airborne pollen levels and drug consumption for seasonal allergic rhinoconjunctivitis: a 10‐year study in France

Efficacité du rituximab dans la prise en charge du syndrome hémolytique et urémique par anticorps anti-facteur H chez l’adulte : à propos d’un cas

Exposition aux pollens et consommation de médicaments anti-allergiques pour rhinite allergique saisonnière à Clermont-Ferrand pendant 10ans

Device-based controlled local delivery of anastrozol into peritoneal cavity: in vitro and in vivo evaluation

Diagnostic de l’allergie alimentaire à la noisette chez l’enfant : il faut rester prudent !

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