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Key points
In the epididymis, elaborate communication networks between epithelial cells are important with respect to establishing an optimal acidic luminal environment for the maturation and storage of spermatozoa, which is essential for male fertility.
Proton secretion by epididymal clear cells is achieved via the proton pumping V‐ATPase located in their apical membrane.
In the present study,...
Key points
Aquaporin‐2 (AQP2) is crucial for water homeostasis, and vasopressin (VP) induces AQP2 membrane trafficking by increasing intracellular cAMP, activating PKA and causing phosphorylation of AQP2 at serine 256, 264 and 269 residues and dephosphorylation of serine 261 residue on the AQP2 C‐terminus.
It is thought that serine 256 is the master regulator of AQP2 trafficking, and its phosphorylation...
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