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Purpose Chemokines undergo alterations during neoplasia. However, knowledge about their functional significance in prostate cancer (PCa) progression is still sparse. Since chemokine (C–C motif) ligand 2 (CCL2) is significantly up-regulated in patients with PCa, aim of the current study was to assess whether CCL2 contributes to invasive behavior of prostate cancer cells in vitro. Methods The human...
We evaluated whether low‐dosed interferon alpha (IFNa) may augment the anti‐tumor potential of the histone deacetylase (HDAC)‐inhibitor valproic acid (VPA) on prostate cancer cells in vitro and in vivo. PC‐3, DU‐145, or LNCaP prostate cancer cells were treated with VPA (1 mM), IFNa (200 U/ml), or with the VPA‐IFNa combination. Tumor cell growth, cell cycle progression, and cell cycle regulating proteins...
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