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Nanochannel‐based confinement effect is a fascinating signal transduction strategy for high‐performance sensing, but only size confinement is focused on while other confinement effects are unexplored. Here, a highly integrated nanochannel‐electrodes chip (INEC) is created and a size/volume‐dual‐confinement enzyme catalysis model for rapid and sensitive bacteria detection is developed. The INEC, by...