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Normal hearing in mammals depends on sound amplification by outer hair cells (OHCs) presumably by their somatic motility and force production. However, the role of OHC force production in cochlear amplification and frequency tuning are not yet fully understood. Currently, available OHC manipulation techniques for physiological or clinical studies are limited by their invasive nature, lack of precision,...
The M2 protein of the influenza virus conducts protons into the virion under external acidic pH. The proton selectivity of the tetrameric channel is controlled by a single histidine (His37), whereas channel gating is accomplished by a single tryptophan (Trp41) in the transmembrane domain of the protein. Aromatic interaction between these two functional residues has been previously observed in Raman...
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