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Exposure of Hansenula polymorpha cells, grown in batch cultures on methanol at 37 °C, to a cold treatment (18 °C) is paralleled by a rapid degradation of peroxisomes present in these cells. Remarkably, the events accompanying organelle degradation at 18 °C are similar to those of selective glucose-induced peroxisome degradation in wild-type cells, described before. This observation was strengthened...
We subjected methanol-grown cells of wild type Hansenula polymorpha simultaneously to nitrogen depletion and excess glucose conditions. Both treatments induce the degradation of peroxisomes, either selective (via excess glucose) or non-selective (via nitrogen limitation). Our combined data strongly suggest that both processes occur simultaneously under these conditions. The implications of these findings...
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