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A very efficient, versatile as well as simple to perform procedure was developed in order to prepare a heterobifunctional amphiphilic PEG–NH 2 derivative which can be used for conjugation to a targeting ligand (such as folic acid). This method proceeds by a mixed solid–liquid phase strategy using a TentaGel ® PAP resin, a copolymer consisting of a polystyrene matrix on which a PEG...
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