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In article number 2003237, Meiping Zhao, Hsian‐Rong Tseng, Yazhen Zhu, and co‐workers present a device for the purification of Ewing sarcoma‐derived extracellular vesicles (EVs) by coupling LINGO‐1 antibodies with the covalent chemistry‐mediated EV capture/release mechanism using a nanostructure‐embedded microchip. The purified EVs can be internalized by recipient cells to transfer the mRNA cargoes,...
Tumor‐derived extracellular vesicles (EVs) play essential roles in intercellular communication during tumor growth and metastatic evolution. Currently, little is known about the possible roles of tumor‐derived EVs in sarcoma because the lack of specific surface markers makes it technically challenging to purify sarcoma‐derived EVs. In this study, a specific purification system is developed for Ewing...
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