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Interaction of antibodies with the neonatal FcRn receptor controls largely the length of their life cycle. Altering the serum persistence of antibodies through modulation of their interaction with the FcRn may be advantageous for achieving high contrast images shortly after application of the radiolabeled antibody tracer or more efficient therapy with fewer administrations. This protocol describes...
Intermediate-sized antibody fragments, such as scFv-CH3 (minibodies) and scFv-Fc, retain high avidity for their antigen due to their nature of bivalency. In addition, the incorporation of the Fc region enables the generation of antibody fragments with a variety of biological functions and pharmacokinetic properties. This protocol describes the isolation of variable genes from hybridoma cells, gene...
Non-invasive, molecular imaging of malignancies using radiolabeled antibodies as tracers is an emerging field that can offer information on staging and response to therapy. Protein engineering approaches enable fully human antibodies to be generated against any novel target and reformatted for optimal properties for positron emission tomography imaging (immunoPET). This chapter describes the steps...
This chapter contains sections titled:
Introduction
Improving Antibody Pharmacokinetics (PK) for immunoPET
Applications of immunoPET in Oncology
Summary
References
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