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TNFα participates in the pathogenesis of atherosclerosis. The effect of immunization against TNFα on development of advanced vascular lesions in atherosclerosis-susceptible apoE-deficient mice was investigated. At 5–7 weeks of age, animals received immunization with either Freunds adjuvant and a recombinant antigenic TNFα molecule (TNF106), Freunds adjuvant alone, or no immunization. All mice received...
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