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Transplantation tolerance remains an elusive goal as B-cell-initiated chronic humoral rejection evades current immunosuppression. B-cell-directed therapy is thus emerging as a key component in achieving transplantation tolerance and long-term graft survival. Here, we propose strategies of B-cell repertoire remodeling to achieve humoral unresponsiveness to donor antigens with implementation of fundamental...
The present review highlights the two areas of research pursuit in our laboratory: (1) the regulation of the autoimmune T cell response to pancreatic islet β cells using the nonobese diabetic (NOD) mouse model of type 1 diabetes and (2) the regulation the T cell response to alloantigens. Our work has established a central role for B lymphocytes in driving both autoimmune and allo-immune T cell responses...
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