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Background: Impairment of hepatic microcirculation in fatty liver is thought to render it more susceptible to the effects of ischaemia–reperfusion injury as compared to non-fatty liver grafts. The present study aimed to investigate the effect of consecutively larger doses of l-arginine on the hepatic microcirculation and tissue oxygenation of fatty liver.Methods: Sprague–Dawley rats (200–250 g) were...
Impairment of hepatic microcirculation in fatty liver has been assumed to reduce tolerance of the liver against ischemia–reperfusion injury. The present study was aimed to investigate the role of nitric oxide (NO) in the regulation of hepatic microcirculation and tissue oxygenation in hepatic steatosis.Sprague–Dawley rats (200–250 g) were fed a 2% cholesterol diet (n = 12) to induce hepatic steatosis...
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