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The current techniques for cell cutting always use a diamond knife with an edge angle larger than 20°. The compression caused by the edge angle may destroy the sample. In this paper, a nano knife with a small edge angle 5° was fabricated from a commercial AFM cantilever by FIB etching. The mechanical character of the nano knife was calibrated by theoretical calculation, numerical simulation and nanorobotic...
Cell-cell adhesion force is important for cell activities. In this paper, a novel cell-cell adhesion force measurement method using nano picker was proposed based on the nanorobotic manipulation system inside an environmental scanning electron microscopy (ESEM). The nano picker was fabricated from atomic force microscopy(AFM) cantilever by focused ion beam(FIB) etching. The spring constant of the...
A compact load sensor we developed uses an AT-cut quartz crystal resonator whose resonance frequency changes under external load, and features high sensitivity, high-speed response, and a wide measurement range. Also it has the superior feature in the temperature and frequency stability. In the past, the quartz crystal resonator had been hardly applied to the load measurement because of low degree...
We propose a buckling nanoneedle as a force sensor for stiffness characterization of single cells. There are notable advantages of using buckling nanoneedle for single cells stiffness characterizations such that severe cell damage from an excessive indentation force could be prevented and large variations in single cells stiffness property could be easily detected either from the dented mark on the...
We performed in-situ measurements of mechanical properties of individual W303 wild-type yeast cells by using a soft nanoneedle inside an integrated environmental scanning electron microscope (ESEM) - nanomanipulator system. Two different spring constants of soft nanoneedles which can buckle from certain applied compression force were used to measure a general local stiffness, i.e. stiffness property...
In this study, characterization of cellular mechanics of W303 yeast cells was conducted using nanoneedles inside an environmental SEM (ESEM). This enhanced ESEM system comprises a standard ESEM instrument as a nanoimaging tool, a cooling stage as a humidity controller for cellular biology and 7 degrees of freedom and linear actuators as nanomanipulator/effector. Four types of nanoneedles were used...
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