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Isoniazid (INH), a first-line drug for tuberculosis control, frequently causes liver injury. Multiple previous reports suggest that CYP3A is involved in INH metabolism, bioactivation and hepatotoxicity, although direct evidence is unavailable. In the current study, wild-type and Cyp3α-null mice were used to determine the potential role of Cyp3a in INH metabolism in vivo. Compared to wild-type mice,...
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