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Background In mammals, inflammation is required for wound repair and tumorigenesis. However, the events that lead to inflammation, particularly in non-healing wounds and cancer, are only partly understood. Findings Mast cells, due to their great plasticity, could orchestrate the inflammatory responses inducing the expression of extraembryonic programs of normal and pathological tissue formation...
The cutaneous wound‐healing reaction occurs in overlapping but inter‐related phases, which ultimately result in fibrosis. The pathophysiological mechanisms involved in fibrotic diseases, including organ‐related and even systemic diseases, such as systemic sclerosis, could represent the successive systemic upregulation of extraembryonic‐like phenotypes, that is, amniotic and vitelline phenotypes. These...
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