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The central nervous system responds to stressful events by activating a generalized neuroendocrine stress response, which is followed by the feedback orchestration of diffuse brain processes that coordinate a strategy for coping with the stress. Ascending brainstem and/or descending limbic circuits converge in the hypothalamus to provide the excitatory drive for the stress activation of the hypothalamic–pituitary–adrenal...
Electrophysiological studies over the past decades have shown that many compounds in addition to 'classical' neurotransmitters affect electrical activity in the brain. These compounds include neuropeptides synthesized in brain as well as compounds which are released from peripheral sources and subsequently enter the brain compartment, such as corticosteroid hormones from the adrenal gland. In the...
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