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Mitophagy, or mitochondrial autophagy, plays an important role in mitochondrial quality control for the selective removal of damaged or unwanted mitochondria. Several molecules, including Parkin, p62 and the mitophagy receptors ATG32, NIX/BNIP3 and FUNDC1, were found to participate selective mitophagy. One critical question is how mitochondrial damage-related signals are sensed and transduced to activate...
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