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The shortage of drugs currently available for the treatment of diabetic complications has aroused our interest for the search of new aldose reductase inhibitors (ARIs) endowed with more favorable biological properties. In response, quantitative structure–activity relationship (QSAR) study has been performed on a series of 5-arylidene-2,4-thiazolidinediones using the Fujita-Ban and the classical Hansch...
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