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Introduction: Mast cells have been implicated in the aetiology of many diseases and are particularly important in evoking leukocyte-endothelial interactions during endotoxemia. Mast cell activity can be modified by histamine. There are only little data available whether serotonin (5-HT), another amine, is involved in alterations of mast cell activity, too. The aim of the study was to investigate the...
Background. The intestinal mucosa is the portion of the gut most susceptible to impaired perfusion and oxygen delivery. The phosphodiesterase (PDE) inhibitor amrinone has been proposed to improve oxygen delivery and tissue perfusion during sepsis. The objective of this study was to investigate the effects of amrinone on arterial oxygenation (Pao 2 ) and tissue oxygenation (Ptio 2 )...
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