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Glucagon-like peptide 2 (GLP-2), produced by enteroendocrine L-cells, regulates intestinal growth. This study investigates circulating and intestinal GLP-2 levels in conditions with altered L-cell exposure to nutrients. Rats were allocated to the following experimental groups: ileal–jejunal transposition, resection of the proximal or distal half of the small intestine, and appropriate sham-operated...
Glucagon-like peptide 2 (GLP-2) is a 33-amino acid (1-33) intestinotrophic peptide. In this study, the distribution and binding of i.v. injected radiolabeled GLP-2 (1-33) were investigated in rats using autoradiography in order to target possible binding sites. The major part of 125 I-GLP-2 (1-33) was distributed to kidneys, liver, and the gastrointestinal tract. In the small intestine,...
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