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To search for association with environmental factors and to determine SQSTM1/p62 mutations prevalence in French families with Paget's disease of bone (PDB).Unrelated patients with a confirmed diagnosis of PDB were recruited in three Rheumatology departments and informed consent obtained. First- and second-degree relatives of each index case had a physical examination, blood taken for DNA extraction...
Rechercher une association avec des facteurs environnementaux et déterminer la prévalence des mutations de SQSTM1/p62 dans des familles françaises avec maladie osseuse de Paget (MOP).Des patients non apparentés avec un diagnostic confirmé de MOP ont été recrutés dans trois services de rhumatologie et un consentement éclairé a été obtenu. Les apparentés au premier et second degré de chaque cas index...
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