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Biological variables specifically linked with serotonin deficiency were assessed in geriatric depression. Sixteen depressed patients, all =< 60 years of age and with scores on the Montgomery- 9sberg Depression Rating Scale (MADRS) =< 20, were treated with fluoxetine (20 mg/day) for 42 days. Biological variables measured on days 1 and 42 included whole blood and plasma serotonin, plasma total...
The effect of month-long naltrexone (NTX) treatment at a daily oral dose of 0.5 mg/kg/day was contrasted with placebo (PLC) in a double-blind study with conjoint clinical and biochemical evaluations of therapeutic effects. Modest clinical benefits were achieved with both PLC and NTX, with marginally better overall results following NTX, and degree of improvement appeared to be related to plasma chemical...
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