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We investigated the subcellular distribution of human ZBP1, which harbors the N-terminal Z-DNA binding domains, Zα and Zβ. ZBP1 was distributed primarily in the cytoplasm and occasionally as nuclear foci in interferon (IFN)-treated primary hepatocellular carcinoma cells, and in several other transfected cell types. In leptomycin B (LMB)-treated cells, endogenous ZBP1 efficiently accumulated in nuclear...
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