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α 2 -ARs regulate brain monoaminergic function by inhibiting neuronal firing and release of monoamine neurotransmitters, noradrenaline (NA), serotonin (5-HT) and dopamine (DA). Both α 2A - and α 2C -AR inhibit monoamine release in vitro in brain slices, but the in vivo roles of individual α 2 -AR subtypes in modulating monoamine metabolism have not been characterised...
Alpha2-adrenergic drugs modulate cortical arousal and EEG. However, the role of individual alpha2-adrenoceptor (α 2 -AR) subtypes in these functions is not clear. We investigated the role of α 2C -ARs in the modulation of baseline cortical EEG activity and EEG responses to the α 2 -AR selective agonist, dexmedetomidine (3-300 μg/kg, s.c.), and antagonist, atipamezole (3-1000...
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