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Imaging the high‐affinity, functional state (HA) of dopamine D2 and D3 receptors has been pursued in PET imaging studies of various brain functions. We report further evaluation of 18F‐5‐OH‐FPPAT, and the newer 18F‐5‐OH‐FHXPAT and 18F‐7‐OH‐FHXPAT. Syntheses of 18F‐5‐OH‐FHXPAT and 18F‐7‐OH‐FHXPAT were improved by modifications of our previously reported procedures. Brain slices and brain homogenates...
Objective: Alzheimer's disease (AD) is a neurodegenerative disease characterized by Aβ plaques in the brain. The aim of this study was to evaluate the effectiveness of a novel radiotracer, 4‐[11C]methylamino‐4′‐N,N‐dimethylaminoazobenzene ([11C]TAZA), for binding to Aβ plaques in postmortem human brain (AD and normal control (NC)). Methods: Radiosyntheses of [11C]TAZA, related [11C]Dalene (11C‐methylamino‐4′‐dimethylaminostyrylbenzene),...
Identification of dopamine D3 receptors (D3R) in vivo is important to understand several brain functions related to addiction. The goal of this work was to identify D3R binding of the dopamine D2 receptor (D2R)/D3R imaging agent, 18F‐fallypride. Brain slices from male Sprague‐Dawley rats (n = 6) and New Zealand White rabbits (n = 6) were incubated with 18F‐fallypride and D3R selective agonist (R)‐7‐OH‐DPAT...
We report the use of β3 adrenergic receptor mediated activation of rat brain frontal cortex using mirabegron (a selective β3 adrenoceptor agonist), measured by 18F‐FDG PET/CT. Another β3 agonist, CL 316,243, did not have this effect due to impermeability through the blood brain barrier (BBB), while atomoxetine, a norepinephrine transporter blocker, did increase 18F‐FDG uptake in the frontal cortex...
Brown adipose tissue (BAT) plays a significant role in metabolism. In this study, we report the use of atomoxetine (a clinically applicable norepinephrine reuptake inhibitor) for 18F‐FDG PET imaging of BAT and its effects on heat production and blood glucose concentration. Fasted‐male Sprague‐Dawley rats were administered with intravenous 18F‐FDG. The same rats were treated with atomoxetine (0.1 mg/kg,...
In this study, we compared two different D2/3 receptor ligands, [18F]fallypride and [18F]desmethoxyfallypride ([18F]DMFP) with respect to the duration of the scan, visualization of extrastriatal receptors, and binding potentials (BPND) in the rat brain. In addition, we studied the feasibility of using these tracers following a period of awake tracer uptake, during which the animal may perform a behavioral...
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