Search results for: Yutaka Imamura

Items from 1 to 20 out of 77 results

article

Fostamatinib for the treatment of Japanese patients with primary immune thrombocytopenia: A phase 3, placebo‐controlled, double‐blind, parallel‐group study

Masataka Kuwana, Tomoki Ito, Shugo Kowata, Yoshihiro Hatta, more

British Journal of Haematology > 200 > 6 > 802 - 811

Fostamatinib, a spleen tyrosine kinase inhibitor, has been approved for the treatment of chronic primary immune thrombocytopenia (ITP) in the United States, Canada and some European countries. We conducted a phase 3, placebo‐controlled, double‐blind, parallel‐group study to evaluate the efficacy and safety of fostamatinib in Japanese patients with primary ITP. Thirty‐four patients were randomised...

article

Predictors of impaired antibody response after SARS‐CoV‐2 mRNA vaccination in hematopoietic cell transplant recipients: A Japanese multicenter observational study

Yasuo Mori, Naoyuki Uchida, Takuya Harada, Yuta Katayama, more

American Journal of Hematology > 98 > 1 > 102 - 111

HCT recipients reportedly have a high mortality rate after developing COVID‐19. SARS‐CoV‐2 vaccination is generally useful to prevent COVID‐19. However, its safety and efficacy among HCT recipients remain elusive. This large‐scale prospective observational study including 543 HCT recipients with 37‐months interval from transplant demonstrated high safety profiles of mRNA vaccine: only 0.9% of patients...

article

De novo generation of optically active small organic molecules using Monte Carlo tree search combined with recurrent neural network

Motomichi Tashiro, Yutaka Imamura, Michio Katouda

Journal of Computational Chemistry > 42 > 3 > 136 - 143

Optically active small organic molecules are computationally designed using the ChemTS python library developed by Tsuda and collaborators, which utilizes a combined Monte Carlo tree search (MCTS) and recurrent neural network model. Geometry optimization and excited‐state calculations are performed for each generated molecule, following which the excitation energy and dissymmetry factors are computed...

article

Anisotropic Poisson Effect and Deformation‐Induced Fluorescence Change of Elastic 9,10‐Dibromoanthracene Single Crystals

Shotaro Hayashi, Fumitaka Ishiwari, Takanori Fukushima, Shohei Mikage, more

Angewandte Chemie International Edition > 59 > 37 > 16195 - 16201

Elastic organic crystals have attracted considerable attention as next‐generation flexible smart materials. However, the detailed information on both molecular packing change and macroscopic mechanical crystal deformations upon applied stress is still insufficient. Herein, we report that fluorescent single crystals of 9,10‐dibromoanthracene are elastically bendable and stretchable, which allows a...

article

Anisotropic Poisson Effect and Deformation‐Induced Fluorescence Change of Elastic 9,10‐Dibromoanthracene Single Crystals

Shotaro Hayashi, Fumitaka Ishiwari, Takanori Fukushima, Shohei Mikage, more

Angewandte Chemie > 132 > 37 > 16329 - 16335

article

Cessation of nilotinib in patients with chronic myelogenous leukemia who have maintained deep molecular responses for 2 years: a multicenter phase 2 trial, stop nilotinib (NILSt)

Koji Nagafuji, Itaru Matsumura, Takayuki Shimose, Tatsuya Kawaguchi, more

International Journal of Hematology > 2019 > 110 > 6 > 675-682

The aim of this multicenter phase 2 trial, Stop Nilotinib (NILSt), was to examine the safety and efficacy of discontinuation of nilotinib in patients with chronic phase (CP)-chronic myelogenous leukemia (CML). Patients with CP-CML who had achieved molecular response (MR^4.5) after initiation of imatinib or nilotinib therapy received consolidation therapy with nilotinib 300–400 mg twice daily for up...

article

Mineralocorticoid receptor inhibitor for long‐standing central serous chorioretinopathy

Azu Suzuki, Yoji Takano, Yasutaka Ando, Junko Ogawa, more

Acta Ophthalmologica > 96 > 5 > e662 - e663

article

Inversion of Optical Activity in the Synthesis of Mercury Sulfide Nanoparticles: Role of Ligand Coordination

Jumpei Kuno, Yutaka Imamura, Michio Katouda, Motomichi Tashiro, more

Angewandte Chemie > 130 > 37 > 12198 - 12202

Optical activity in inorganic colloidal materials was controlled through interactions of chiral molecules with the nanoparticle (NP) surface. An inversion of optical activity in the synthesis of mercury sulfide (HgS) NPs was demonstrated with an intrinsically chiral crystalline system in the presence of an identical chiral capping ligand. A continuous decrease in the positive first Cotton effect and...

article

Inversion of Optical Activity in the Synthesis of Mercury Sulfide Nanoparticles: Role of Ligand Coordination

Jumpei Kuno, Yutaka Imamura, Michio Katouda, Motomichi Tashiro, more

Angewandte Chemie International Edition > 57 > 37 > 12022 - 12026

article

Inner Nuclear Layer Thickness, a Biomarker of Metamorphopsia in Epiretinal Membrane, Correlates With Tangential Retinal Displacement

Yoshikazu Ichikawa, Yutaka Imamura, Masahiro Ishida

American Journal of Ophthalmology > 2018 > 193 > C > 20-27

To examine correlations of inner nuclear layer (INL) thickness with metamorphopsia and tangential retinal displacement in epiretinal membrane (ERM).Retrospective, consecutive, interventional case series.Setting: Institutional study. Patient Population: Fifty eyes of 50 patients undergoing epiretinal membrane surgery. Observation Procedures: M-CHARTS were used to measure metamorphopsia. Inner nuclear...

article

Extrapolation of polymer gap by combining cluster and periodic boundary condition calculations with Hückel theory

Yutaka Imamura, Motomichi Tashiro, Michio Katouda, Masahiko Hada

Chemical Physics Letters > 2018 > 707 > C > 44-48

This study has proposed a Hückel theory-based extrapolation scheme for estimating the highest occupied molecular orbital (HOMO)-the lowest unoccupied molecular orbital (LUMO) gap of polymers without resorting to periodic boundary condition calculations using plane wave functions with hybrid functionals. The extrapolation scheme similar to ONIOM combines pure density functional theory (DFT) using plane...

article

Theoretical study on naphthobischalcogenadiazole conjugated polymer systems and C61 derivative as organic photovoltaic semiconductors

Takehiro Fujita, Toru Matsui, Masato Sumita, Yutaka Imamura, more

Chemical Physics Letters > 2018 > 693 > C > 188-193

We investigated the charge-transfer reactions of solar cells including a quaterthiophene copolymer with naphtho-bis-thiadiazole (PNTz4T) and naphtho-bis-oxadiazole (PNOz4T) using constrained density functional theory (CDFT). According to our calculations, the high electron-transfer rate results in a highly efficient solar cell, and the stable charge-transfer state results in low energy loss. Our computations...

article

Retinal thinning after internal limiting membrane peeling for idiopathic macular hole

Yutaka Imamura, Masahiro Ishida

Japanese Journal of Ophthalmology > 2018 > 62 > 2 > 158-162

Purpose To determine the changes in retinal thickness and whether they correlate with the size of the macular hole (MH) after vitrectomy with internal limiting membrane peeling. Study design Retrospective, interventional case series Methods Consecutive patients with an MH and undergoing pars plana vitrectomy with internal limiting membrane peeling were studied. The retinal thicknesses in the inner...

article

Identifying potential habitat distribution of the neon flying squid (Ommastrephes bartramii) off the eastern coast of Japan in winter

Hiromichi Igarashi, Sei‐Ichi Saitoh, Yoichi Ishikawa, Masafumi Kamachi, more

Fisheries Oceanography > 27 > 1 > 16 - 27

Habitat suitability index (HSI) models were applied to identify the potential habitat distribution of the neon flying squid (Ommastrephes bartramii) off the eastern coast of Japan during winter. We used an ocean reanalysis product, a satellite‐derived dataset, and commercial fisheries data during 2003–2008 to develop the HSI models, and illustrated the characteristics of the ocean environments at...

article

Theoretical study on spin-forbidden transitions of osmium complexes by two-component relativistic time-dependent density functional theory

Yutaka Imamura, Muneaki Kamiya, Takahito Nakajima

Chemical Physics Letters > 2016 > 648 > C > 60-65

We study spin-forbidden transitions of Os polypyridyl sensitizers by two-component relativistic time-dependent density functional theory with the spin–orbit interaction based on Tamm–Dancoff approximation. The absorption spectra, including spin-forbidden-transition peaks, for the Os complexes are reasonably reproduced in comparison with the experimental ones. The extension of the conjugated lengths...

chapter

Habitat suitability index Model for neon flying squid adding its stock effect

Hiromichi Igarashi, Yoichi Ishikawa, Haruka Nishikawa, Norihisa Usui, more

2016 Techno-Ocean (Techno-Ocean) > 449 - 453

2016 Techno-Ocean (Techno-Ocean)

We constructed the habitat suitability index (HSI) model of the winter-spring cohort of neon flying squid (Ommastrephes bartramii) for the estimate of its potential fishing zone off shore of Sanriku coast by applying Generalized Additive Model (GAM), which includes the stock term describing the effect of interannual change in the squid stocks. The results demonstrated that a significant improvement...

article

Two-component relativistic time-dependent density functional theory study on spin-forbidden transitions for metal polypyridyl complexes

Yutaka Imamura, Muneaki Kamiya, Takahito Nakajima

Chemical Physics Letters > 2015 > 635 > C > 152-156

Spin-forbidden transitions of metal polypyridyl sensitizers are studied by the two-component relativistic time-dependent density functional theory with spin–orbit interaction based on Tamm–Dancoff approximation. The spin-forbidden transitions for a phosphine-coordinated Ru(II), DX1, as well as the modified DX1 complexes whose Ru is replaced with Fe and Os, are calculated. The role of the central metals...

article

One-Year Outcomes with Half-Dose Verteporfin Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

Kyoko Fujita, Yutaka Imamura, Kei Shinoda, Celso Soiti Matsumoto, more

Ophthalmology > 2015 > 122 > 3 > 555-561

To assess the 1-year outcome of half-dose verteporfin photodynamic therapy (PDT) for patients with chronic central serous chorioretinopathy (CSC).Retrospective, interventional case series with no controls.A total of 204 eyes of 204 patients with chronic CSC were studied.Fluorescein angiography (FA) and indocyanine green angiography (ICGA) were performed before PDT. The best-corrected visual acuities...

article

Local response dispersion method in periodic systems: Implementation and assessment

Yasuhiro Ikabata, Yusuke Tsukamoto, Yutaka Imamura, Hiromi Nakai

Journal of Computational Chemistry > 36 > 5 > 303 - 311

We report the implementation of the local response dispersion (LRD) method in an electronic structure program package aimed at periodic systems and an assessment combined with the Perdew–Burke–Ernzerhof (PBE) functional and its revised version (revPBE). The real‐space numerical integration was implemented and performed exploiting the electron distribution given by the plane‐wave basis set. The dispersion‐corrected...

article

Linearity condition for orbital energies in density functional theory (V): Extension to excited state calculations

Yutaka Imamura, Kensei Suzuki, Takeshi Iizuka, Hiromi Nakai

Chemical Physics Letters > 2015 > 618 > C > 30-36

A new scheme is proposed for constructing an orbital-specific (OS) exchange-correlation functional that satisfies multiple linearity conditions for orbital energies (LCOEs). The Hartree–Fock exchange portions in the OS exchange-correlation functional, based on a multiply range-separated functional, are set so as to satisfy the multiple LCOEs. The current scheme has also been extended to calculations...

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Keywords

OPTICAL COHERENCE TOMOGRAPHY (4)
ANISOTROPIC POISSON EFFECT (2)
DENSITY FUNCTIONAL THEORY (2)
DFT SIMULATION (2)
ELASTIC ORGANIC CRYSTALS (2)
FLUORESCENCE (2)
HARTREE‐FOCK EXCHANGE (2)
MINIMUM SPANNING TREE (2)
MOLECULAR ASSEMBLY (2)
NEON FLYING SQUID (2)
ORBITAL‐SPECIFIC HYBRID FUNCTIONAL (2)
OSELTAMIVIR RESISTANCE (2)
PANDEMIC INFLUENZA A VIRUS (H1N1) 2009 (2)
QUASI-SPECIES (2)
3D‐VAR OCEAN REANALYSIS (1)
ADVANCED GLYCATION END PRODUCTS (1)
AGE-RELATED MACULAR DEGENERATION (1)
ALKOXYSILANES (1)
AMINES (1)
ANGIOTENSIN II (1)
ANGIOTENSIN-CONVERTING ENZYME (1)
ANTERIOR ISCHEMIC OPTIC NEUROPATHY (1)
ANTIVASOGENIC TREATMENT (1)
AQUACULTURE (1)
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ATYPICAL MEGAKARYOCYTE (1)
AUTO-PBSCT (1)
AVELLINO CORNEAL DYSTROPHY (1)
BERNARD–SOULIER SYNDROME (1)
BIOLOGICAL SYSTEM MODELING (1)
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CESSATION (1)
CHARGE TRANSFER (1)
CHIRALITY (1)
CHIRALITÄT (1)
CHOP (1)
CHOROIDAL FOLD (1)
CHOROIDAL STRIAE (1)
CHRONIC MYELOGENOUS LEUKEMIA (1)
CIRCULAR DICHROISM (1)
CIRCULARLY POLARIZED LUMINESCENCE (1)
CONE OUTER SEGMENT TIPS (1)
CONGENITAL GLAUCOMA (1)
CONTRAST SENSITIVITY (1)
COORDINATION (1)
COPPER AMINE OXIDASE (1)
DE NOVO DESIGN (1)
DIABETES (1)
DIABETIC RETINOPATHY (1)
DISC AT RISK (1)
DISCONTINUATION (1)
DISPERSION FORCE (1)
DLBCL (1)
ENERGY DECOMPOSITION • KULLBACK‐LEIBLER INFORMATION DEFICIENCY (1)
EXTRAMEDULLARY HEMATOPOIESIS (1)
EXTRAPOLATION (1)
FLUORESCEIN ANGIOGRAPHY (1)
FOSTAMATINIB (1)
GABA (1)
GAM (1)
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GPIX (1)
GRANULAR CORNEAL DYSTROPHY (1)
HABITAT MODEL (1)
HABITAT SUITABILITY (1)
HAIR (1)
HIRSHFELD PARTITIONING • WEIZÄCKER PARTITIONING • KINETIC ENERGY DENSITY • VIRIAL RATIO (1)
HOMOGENEITY (1)
HYBRID FUNCTIONAL (1)
HÜCKEL THEORY (1)
INDEX MODEL (1)
INDOCYANINE GREEN ANGIOGRAPHY (1)
INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY (1)
INTERLEUKIN-6 (1)
INTERNAL LIMITING MEMBRANE PEELING (1)
IONIZATION POTENTIAL (1)
JAK2V617F MUTATION (1)
JAPANESE (1)
KERATO-EPITHELIN MUTATION (1)
KOORDINATION (1)
LATTICE CORNEAL DYSTROPHY (1)
LEAD (1)
LEWIS ACIDS (1)
LINEARITY CONDITION (1)
LINEARITY CONDITION FOR ORBITAL ENERGIES (1)
LINEARITY CONDITION FOR ORBITAL ENERGY (1)
LIVER GLYCOGEN STORAGE (1)
LOW LUMINANCE VISUAL ACUITY (1)
MACROTHROMBOCYTOPENIA (1)
MACULAR HOLE (1)
MACULAR HOLE SIZE (1)
MAURIAC SYNDROME (1)
MERCURY SULFIDE (1)
MILITARY TUBERCULOSIS (1)
MONTE CARLO TREE SEARCH (1)
MOOD (1)
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American Journal of Ophthalmology (12)
Chemical Physics Letters (10)
Ophthalmology (6)
International Journal of Hematology (4)
Journal of Computational Chemistry (4)
Acta Ophthalmologica (3)
Genomics (3)
Japanese Journal of Ophthalmology (3)
Angewandte Chemie (2)
Angewandte Chemie International Edition (2)
Cancer Science (2)
Diabetes Research and Clinical Practice (2)
Graefe's Archive for Clinical and Experimental Ophthalmology (2)
Journal of Infection and Chemotherapy (2)
Survey of Ophthalmology (2)
American Journal of Hematology (1)
Biochemical and Biophysical Research Communications (1)
Biological Trace Element Research (1)
British Journal of Haematology (1)
Clinical and Experimental Optometry (1)
Fisheries Oceanography (1)
Gene (1)
International Journal of Quantum Chemistry (1)
International Ophthalmology (1)
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Journal of Organometallic Chemistry (1)
Pathology International (1)
Procedia Computer Science (1)
The American Journal of Human Genetics (1)
The American Journal of Pathology (1)
The Arts in Psychotherapy (1)
The Journal of Physical Chemistry A (1)
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INFONA - science communication portal

Search results for: Yutaka Imamura

Fostamatinib for the treatment of Japanese patients with primary immune thrombocytopenia: A phase 3, placebo‐controlled, double‐blind, parallel‐group study

Predictors of impaired antibody response after SARS‐CoV‐2 mRNA vaccination in hematopoietic cell transplant recipients: A Japanese multicenter observational study

De novo generation of optically active small organic molecules using Monte Carlo tree search combined with recurrent neural network

Anisotropic Poisson Effect and Deformation‐Induced Fluorescence Change of Elastic 9,10‐Dibromoanthracene Single Crystals

Anisotropic Poisson Effect and Deformation‐Induced Fluorescence Change of Elastic 9,10‐Dibromoanthracene Single Crystals

Cessation of nilotinib in patients with chronic myelogenous leukemia who have maintained deep molecular responses for 2 years: a multicenter phase 2 trial, stop nilotinib (NILSt)

Mineralocorticoid receptor inhibitor for long‐standing central serous chorioretinopathy

Inversion of Optical Activity in the Synthesis of Mercury Sulfide Nanoparticles: Role of Ligand Coordination

Inversion of Optical Activity in the Synthesis of Mercury Sulfide Nanoparticles: Role of Ligand Coordination

Inner Nuclear Layer Thickness, a Biomarker of Metamorphopsia in Epiretinal Membrane, Correlates With Tangential Retinal Displacement

Extrapolation of polymer gap by combining cluster and periodic boundary condition calculations with Hückel theory

Theoretical study on naphthobischalcogenadiazole conjugated polymer systems and C61 derivative as organic photovoltaic semiconductors

Retinal thinning after internal limiting membrane peeling for idiopathic macular hole

Identifying potential habitat distribution of the neon flying squid (Ommastrephes bartramii) off the eastern coast of Japan in winter

Theoretical study on spin-forbidden transitions of osmium complexes by two-component relativistic time-dependent density functional theory

Habitat suitability index Model for neon flying squid adding its stock effect

Two-component relativistic time-dependent density functional theory study on spin-forbidden transitions for metal polypyridyl complexes

One-Year Outcomes with Half-Dose Verteporfin Photodynamic Therapy for Chronic Central Serous Chorioretinopathy

Local response dispersion method in periodic systems: Implementation and assessment

Linearity condition for orbital energies in density functional theory (V): Extension to excited state calculations

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