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The intracellular fate of particulate drug delivery systems is determined by the initial mode of internalization and the subsequent intracellular trafficking. Besides clathrin-mediated endocytosis, different cellular uptake mechanisms for internalization are discussed, including caveolae-mediated endocytosis, phagocytosis, macropinocytosis and the badly characterized non-clathrin–non-caveolae-mediated...
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