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Monosialogangliosides, normal components of cell membranes, regulate cell development and differentiation in several organs. Our previous observation of dramatic premature thymic involution in cats with feline GM1 gangliosidosis, whose thymocytes have abnormally high cell surface gangliosides, suggested that excess GM1 ganglioside (GM1) could modulate thymocyte apoptosis in this disease (Coxet al...
We demonstrated previously that ethanol enhances apoptosis of murine thymocytes. In this report, we determined intracellular cAMP and cytosolic free calcium ([Ca 2+ ] i ) levels in mouse thymocytes following acute exposure to ethanol and investigated the involvement of cAMP, [Ca 2+ ] i , protein kinase A (PKA), and protein kinase C (PKC) in thymocyte apoptotic...
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