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Cyclic GMP‐AMP synthase (cGAS) is essential for fighting against viruses and bacteria, but how cGAS is involved in host immune response remains largely elusive. Here, we uncover the crucial role of cGAS in host immunity based on a Pseudomonas aeruginosa pulmonary infection model. cGAS−/− mice showed more heavy bacterial burdens and serious lung injury accompanied with exorbitant proinflammatory cytokines...
The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR‐associated systems (CRISPR‐Cas) systems in prokaryotes function at defending against foreign DNAs, providing adaptive immunity to maintain homeostasis. CRISPR‐Cas may also influence immune regulation ability in mammalian cells through alterations of pathogenic extent and nature. Recent research has implied that Type...
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