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Effects of morphine withdrawal on the levels of preproenkephalin (PPE) mRNA in the area from lateral to ventrolateral periaqueductal gray (PAG) were studied in rats by quantitative in situ hybridization. PPE mRNA in the rostral PAG was decreased by naloxone-precipitated morphine withdrawal but not affected by spontaneous morphine withdrawal. PPE mRNA in the caudal PAG was increased by both spontaneous...
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