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We have previously shown that immunization to homologous LDL reduces neointimal thickening after balloon injury in hypercholesterolemic rabbits. In this study we investigated the effects of the immune system on intimal thickening after arterial injury in RAG (recombination activating gene)-1 deficient (-/-) mice. The arterial injury was induced by placing of a plastic cuff around the carotid artery...
We tested the hypothesis that recombinant apolipoprotein A-I Milano -phospholipid complex (A-I M -PC) would inhibit aortic atherosclerosis (AS) in apoE-deficient mice. Control apoE-deficient mice, fed a high-cholesterol diet, were sacrificed at 20 (n = 8) or 25 weeks (N = 7). Treated mice received 40 mg/kg/dose A-I M -PC (n = 15) or PC alone (n =...
Because of increasing evidence that human cytomegalovirus (CMV) pre-disposes to atherosclerosis, we determined whether different immune responses to CMV occur in immunocompetent individuals and, if so, whether the specific type of immune response correlates with coronary artery disease (CAD). 166 patients (pts) (64% men, 36% women, mean age 57) being evaluated for CAD were studied. Blood samples...
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