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N‐substituted maleimides were synthesized from maleic anhydride and primary amines. 1,4‐Dibromo‐dibenzo[e,h]bicyclo‐[2,2,2]octane‐2,3‐dicarboximide derivatives (4a–f) were prepared by the [4+2] cycloaddition reaction of dibromoanthracenes with the N‐substituted maleimide derivatives. The carbonic anhydrase (CA, EC 4.2.1.1) inhibitory effects of the new derivatives were assayed against the human (h)...
Reactions of amino, aminomethyl tetralins and benzyl alcohol with chlorosulphonyl isocyanate (CSI) afforded sulphamoyl carbamates. The sulphamoyl carbamates were converted to sulphamides by palladium‐catalysed hydrogenolysis. Sulphonamides were synthesized from the reactions of amines with MeSO2Cl. Inhibition of human (h) carbonic anhydrase (CA) isoenzymes (hCA I, hCA II) and acetylcholine esterase...
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