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We have measured the solubility, and the rates of homogeneous and heterogeneous nucleation on sickle hemoglobin (HbSβ6 Glu->Val) additionally modified by site-directed mutagenesis to possess Ala rather than Leu at β88, which forms part of the receptor site for β6 Val in the sickle polymer. The solubility of the hemoglobin is increased at all temperatures, and is about 29 g/dl at 25 o C...
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