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Due to the public health impact of prostate cancer including the burden of screening and treatment, there is significant public interest in the potential prevention of this disease. We review the most recent results of large scale randomized clinical trials.We review the potential agents, their hypothesized mechanisms of action and challenges for the design of chemoprevention trials, including the...
It is now possible to reduce a man's risk of developing biopsy-detectable prostate cancer. This review addresses the evidence and issues surrounding prostate cancer risk reduction.The scientific basis, therapeutic approach, and risks and benefits of prostate cancer prevention are reviewed. Special attention is given to data on 5α-reductase inhibitors (5-ARIs).Medline searches consisted of articles...
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