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The effect of pre- and post-challenge treatments with trifluoperazine and palmitoylcarnitine, two protein kinase C (PKC) inhibitors characterised by their interaction with the phospholipid enzyme cofactor, on the inflammation caused by delayed hypersensitivity (DTH) to dinitrofluorobenzene (DNFB) and sheep red blood cells (SRBC) in mice is reported. The activity of dexamethasone and two immunosupressors,...
The activity of the Santolina chamaecyparissus methanol extract was tsted against the phospholipase A 2 (PLA 2 )-induced mouse paw edema and in vitro inhibition of PLA 2 activity. After fractionation, only the dichloromethane extract was active against the PLA 2 in vitro test. In addition, it reduced the edema induced by arachidonic acid, and by 12-O-tetradecanoylphorbol-13-acetate...
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