Search results for: Janne T. Backman

Items from 1 to 20 out of 75 results

article

Posaconazole‐ibrutinib interaction cannot be avoided by staggered dosing: How to optimize ibrutinib dose during posaconazole treatment

Aleksi M. Olkkola, Tuija Tapaninen, Aleksi Tornio, Milka Hauta‐aho, more

British Journal of Clinical Pharmacology > 90 > 2 > 557 - 567

Aims Ibrutinib is used in the treatment of certain B‐cell malignancies. Due to its CYP3A4‐mediated metabolism and highly variable pharmacokinetics, it is prone to potentially harmful drug‐drug interactions. Methods In a randomized, placebo‐controlled, three‐phase crossover study, we examined the effect of the CYP3A4‐inhibiting antifungal posaconazole on ibrutinib pharmacokinetics. Eleven healthy...

article

Drug‐related deaths in a university hospital: Comparison to previous decades

Mirjam Kauppila, Janne T. Backman, Mikko Niemi, Outi Lapatto‐Reiniluoto

Basic & Clinical Pharmacology & Toxicology > 134 > 1 > 165 - 174

The incidence of fatal adverse drug reactions (ADRs) in hospitals varies widely, and ADRs are often underreported. The impact of medical safety processes is not easily evaluated, and although medical practice changes constantly, little is known about ADR trends. This study concentrated on the current incidence and properties of fatal ADRs occurring in a university hospital and compared the results...

article

Introduction of an electrochemical point‐of‐care assay for quantitative determination of paracetamol in finger‐prick capillary whole blood samples

Johanna Kujala, Niklas Wester, Terhi J. Lohela, Mika Kurkela, more

British Journal of Clinical Pharmacology > 89 > 9 > 2933 - 2938

Aims Measuring venous plasma paracetamol concentrations is time‐ and resource‐consuming. We aimed to validate a novel electrochemical point‐of‐care (POC) assay for rapid paracetamol concentration determinations. Methods Twelve healthy volunteers received 1 g oral paracetamol, and its concentrations were analysed 10 times over 12 h for capillary whole blood (POC), venous plasma (high‐performance...

article

Medicines, environment and clinical pharmacology

Outi Lapatto‐Reiniluoto, Mia Siven, Janne T. Backman, Anneli Törrönen

Basic & Clinical Pharmacology & Toxicology > 131 > 2 > 149 - 152

Medical associations and other societies have announced their theses on protection of the climate and environmental aspects in medicine. The challenges with climate change and sustainability are complex, and no quick solutions are to be found. However, basic knowledge on these issues should be available to everyone, and environmental aspects of drugs are important to all healthcare professionals....

article

Translational aspects of cytochrome P450‐mediated drug–drug interactions: A case study with clopidogrel

Aleksi Tornio, Anne M. Filppula, Janne T. Backman

Basic & Clinical Pharmacology & Toxicology > 130 > S1 > 48 - 59

Multimorbidity, polypharmacotherapy and drug interactions are increasingly common in the ageing population. Many drug–drug interactions (DDIs) are caused by perpetrator drugs inhibiting or inducing cytochrome P450 (CYP) enzymes, resulting in alterations of the plasma concentrations of a victim drug. DDIs can have a major negative health impact, and in the past, unrecognized DDIs have resulted in drug...

article

Professor Pertti Jaakko Neuvonen (25 August 1943‐14 May 2020)

Janne T. Backman, Mikko Niemi

Basic & Clinical Pharmacology & Toxicology > 128 > 4 > 553 - 554

article

Relationship of Edoxaban Plasma Concentration and Blood Coagulation in Healthy Volunteers Using Standard Laboratory Tests and Viscoelastic Analysis

Martina Havrdová, Teijo I. Saari, Jouko Jalonen, Marko Peltoniemi, more

The Journal of Clinical Pharmacology > 61 > 4 > 522 - 530

The capability of viscoelastic measurement parameters to screen anticoagulation activity of edoxaban in relation to its plasma concentrations was evaluated in 15 healthy male volunteers. Blood samples were drawn before the oral administration of edoxaban 60 mg and 2, 4, 6, 8, and 24 hours after administration. At each time, standard coagulation tests were performed, blood viscoelastic properties were...

article

In Vitro Screening of Six Protein Kinase Inhibitors for Time‐Dependent Inhibition of CYP2C8 and CYP3A4: Possible Implications with regard to Drug–Drug Interactions

Anne M. Filppula, Tiffany M. Mustonen, Janne T. Backman

Basic & Clinical Pharmacology & Toxicology > 123 > 6 > 739 - 748

Several protein kinase inhibitors have been reported to affect cytochrome P450 (CYP) 3A by time‐dependent inhibition. Herein, we tested a set of six kinase inhibitors for time‐dependent inhibition of CYP2C8 and CYP3A4 in human liver microsomes. Dovitinib, midostaurin and nintedanib exhibited an increased inhibition of CYP3A4 after a 30‐min. pre‐incubation with NADPH, as compared to no pre‐incubation...

article

Voriconazole greatly increases the exposure to oral buprenorphine

Mari Fihlman, Tuija Hemmilä, Nora M. Hagelberg, Janne T. Backman, more

European Journal of Clinical Pharmacology > 2018 > 74 > 12 > 1615-1622

Purpose Buprenorphine has low oral bioavailability. Regardless of sublingual administration, a notable part of buprenorphine is exposed to extensive first-pass metabolism by the cytochrome P450 (CYP) 3A4. As drug interaction studies with buprenorphine are limited, we wanted to investigate the effect of voriconazole, a strong CYP3A4 inhibitor, on the pharmacokinetics and pharmacodynamics of oral buprenorphine...

article

Implications of intercorrelation between hepatic CYP3A4‐CYP2C8 enzymes for the evaluation of drug–drug interactions: a case study with repaglinide

Kosuke Doki, Adam S. Darwich, Brahim Achour, Aleksi Tornio, more

British Journal of Clinical Pharmacology > 84 > 5 > 972 - 986

Aims Statistically significant positive correlations are reported for the abundance of hepatic drug‐metabolizing enzymes. We investigate, as an example, the impact of CYP3A4–CYP2C8 intercorrelation on the predicted interindividual variabilities of clearance and drug–drug interactions (DDIs) for repaglinide using physiologically based pharmacokinetic (PBPK) modelling. Methods PBPK modelling and...

article

Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects

Mikko Neuvonen, E. Katriina Tarkiainen, Aleksi Tornio, Päivi Hirvensalo, more

Basic & Clinical Pharmacology & Toxicology > 122 > 3 > 341 - 345

Several single nucleotide variations (SNVs) affect carboxylesterase 1 (CES1) activity, but the effects of genetic variants on CES1 gene expression have not been systematically investigated. Therefore, our aim was to investigate effects of genetic variants on CES1 gene expression in two independent whole blood sample cohorts of 192 (discovery) and 88 (replication) healthy volunteers and in a liver...

article

Identification of novel genetic variants associated with membrane transporter, drug metabolizing enzyme and nuclear receptor gene expression in whole blood

Mikko Neuvonen, Päivi Hirvensalo, Aleksi Tornio, Katriina Tarkiainen, more

Drug Metabolism and Pharmacokinetics > 2017 > 32 > 1 Supplement > S32

article

Effects of carboxylesterase 1 single nucleotide variations on the pharmacokinetics and pharmacydynamics of clopidogrel

E. Katriina Tarkiainen, Mikko Neuvonen, Aleksi Tornio, Mikko T. Holmberg, more

Drug Metabolism and Pharmacokinetics > 2017 > 32 > 1 Supplement > S111

article

Glucuronidation of clopidogrel by human UGT enzymes: Major contributions by UGT2B7 and UGT2B17

Helinä Kahma, Anne M. Filppula, Mikko Neuvonen, Aleksi Tornio, more

Drug Metabolism and Pharmacokinetics > 2017 > 32 > 1 Supplement > S36

article

UDP-glucuronosyltransferase catalyzed drug bioactivation: Mechanisms and potential for clinically significant drug-drug interactions

Janne T. Backman

Drug Metabolism and Pharmacokinetics > 2017 > 32 > 1 Supplement > S20

article

Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction

Mari Fihlman, Tuija Hemmilä, Nora M. Hagelberg, Kristiina Kuusniemi, more

European Journal of Clinical Pharmacology > 2016 > 72 > 11 > 1363-1371

Purpose This study aimed to determine possible effects of voriconazole and posaconazole on the pharmacokinetics and pharmacological effects of sublingual buprenorphine. Methods We used a randomized, placebo-controlled crossover study design with 12 healthy male volunteers. Subjects were given a dose of 0.4 mg (0.6 mg during placebo phase) sublingual buprenorphine after a 5-day oral pretreatment...

chapter

Using Hilbert-Huang Transform to assess EEG slow wave activity during anesthesia in post-cardiac arrest patients

Jukka Kortelainen, Eero Vayrynen, Usko Huuskonen, Jouko Laurila, more

2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) > 1850 - 1853

2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Hypoxic ischemic encephalopathy (HIE) is a severe consequence of cardiac arrest (CA) representing a substantial diagnostic challenge. We have recently designed a novel method for the assessment of HIE after CA. The method is based on estimating the severity of the brain injury by analyzing changes in the electroencephalogram (EEG) slow wave activity while the patient is exposed to an anesthetic drug...

article

Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60‐year‐old Caucasian woman with ovarian carcinoma

Troels K. Bergmann, Anne M. Filppula, Terhi Launiainen, Flemming Nielsen, more

British Journal of Clinical Pharmacology > 81 > 2 > 313 - 315

AimThe aim of the present case report was to describe a novel pharmacokinetic drug–drug interaction between the antiplatelet agent clopidogrel and the antineoplastic agent paclitaxel. MethodsThe patient was identified in a previously described cohort of 93 patients with ovarian carcinoma treated with paclitaxel. The effect of clopidogrel acyl‐β‐D‐glucuronide on the metabolism of paclitaxel was assessed...

article

Drug‐Related Inadvertent Deaths in a University Hospital – A Declining Trend

Outi Lapatto‐Reiniluoto, Laura Patinen, Mikko Niemi, Janne T. Backman, more

Basic & Clinical Pharmacology & Toxicology > 117 > 6 > 421 - 426

We studied the incidence of fatal adverse drug reactions (ADRs) in a tertiary hospital to find out which drugs were involved. The secondary objective was to compare the data from the same hospital published 12 years earlier. All 1708 death cases in the Helsinki University Central Hospital during the year 2012 were retrospectively evaluated. All suspected drug‐related deaths, excluding suicides, were...

article

Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril

E. Katriina Tarkiainen, Aleksi Tornio, Mikko T. Holmberg, Terhi Launiainen, more

British Journal of Clinical Pharmacology > 80 > 5 > 1131 - 1138

AimThe aim of the present study was to investigate the effects of the carboxylesterase 1 (CES1) c.428G > A (p.G143E, rs71647871) single nucleotide variation (SNV) on the pharmacokinetics of quinapril and enalapril in a prospective genotype panel study in healthy volunteers. MethodsIn a fixed‐order crossover study, 10 healthy volunteers with the CES1 c.428G/A genotype and 12 with the c.428G/G genotype...

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INFONA - science communication portal

Search results for: Janne T. Backman

Posaconazole‐ibrutinib interaction cannot be avoided by staggered dosing: How to optimize ibrutinib dose during posaconazole treatment

Drug‐related deaths in a university hospital: Comparison to previous decades

Introduction of an electrochemical point‐of‐care assay for quantitative determination of paracetamol in finger‐prick capillary whole blood samples

Medicines, environment and clinical pharmacology

Translational aspects of cytochrome P450‐mediated drug–drug interactions: A case study with clopidogrel

Professor Pertti Jaakko Neuvonen (25 August 1943‐14 May 2020)

Relationship of Edoxaban Plasma Concentration and Blood Coagulation in Healthy Volunteers Using Standard Laboratory Tests and Viscoelastic Analysis

In Vitro Screening of Six Protein Kinase Inhibitors for Time‐Dependent Inhibition of CYP2C8 and CYP3A4: Possible Implications with regard to Drug–Drug Interactions

Voriconazole greatly increases the exposure to oral buprenorphine

Implications of intercorrelation between hepatic CYP3A4‐CYP2C8 enzymes for the evaluation of drug–drug interactions: a case study with repaglinide

Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects

Identification of novel genetic variants associated with membrane transporter, drug metabolizing enzyme and nuclear receptor gene expression in whole blood

Effects of carboxylesterase 1 single nucleotide variations on the pharmacokinetics and pharmacydynamics of clopidogrel

Glucuronidation of clopidogrel by human UGT enzymes: Major contributions by UGT2B7 and UGT2B17

UDP-glucuronosyltransferase catalyzed drug bioactivation: Mechanisms and potential for clinically significant drug-drug interactions

Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction

Using Hilbert-Huang Transform to assess EEG slow wave activity during anesthesia in post-cardiac arrest patients

Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60‐year‐old Caucasian woman with ovarian carcinoma

Drug‐Related Inadvertent Deaths in a University Hospital – A Declining Trend

Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril

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