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Human amylin (hA), which is toxic to islet β-cells, can self-generate H 2 O 2 , and this process is greatly enhanced in the presence of Cu(II) ions. Here we show that carbonyl groups, a marker of oxidative modification, were formed in hA incubated in the presence of Cu(II) ions or Cu(II) ions plus H 2 O 2 , but not in the presence of H 2 O 2 alone. Furthermore,...
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