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Hydrogels loaded with biologics hold great potential for various biomedical applications such as regenerative medicine. However, biologics may lose bioactivity during hydrogel preparation, shipping, and storage. While many injectable hydrogels do not have this issue, they face a dilemma between fast gelation causing the difficulty of injection and slow gelation causing the escape of solutions from...
Nanofluidic Devices
A nanofluidic aptamer nanoarray (NANa) enables the stochastic capture of single proteins at normal high concentrations from samples with ultrasmall volumes equivalent to a single cell by following Poisson statistics, forming a readily addressable single‐protein nanoarray. This approach offers a methodology and device that surpass both the concentration and volume limits of single‐protein...
Single‐molecule experiments allow understanding of the diversity, stochasticity, and heterogeneity of molecular behaviors and properties hidden by conventional ensemble‐averaged measurements. They hence have great importance and significant impacts in a wide range of fields. Despite significant advances in single‐molecule experiments at ultralow concentrations, the capture of single molecules in solution...