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We previously found that adeno-associated viral vector serotype 2 (AAV-2) muscle gene delivery of GAD 500–585 autoantigen efficiently prevented autoimmune diabetes in NOD mice. Recent reports suggest that AAV vectors based on serotype 1 (AAV-1) transduce murine skeletal muscle much more efficiently than AAV-2, with reported increases in expression ranging from 2 to 1000-fold. To determine...
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