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Mechanisms of chronic pain, including neuropathic pain, are poorly understood. Upregulation of voltage-gated calcium channel (VGCC) α 2 δ 1 subunit (Ca v α 2 δ 1 ) in sensory neurons and dorsal spinal cord by peripheral nerve injury has been suggested to contribute to neuropathic pain. To investigate the mechanisms without the influence of other injury factors,...
Ectopic spontaneous discharges (ESD) of teased myelinated fibers were recorded from the sciatic nerve proximal to the site of 'chronic constriction nerve injury' in the rat. Ca 2+ , Mg 2+ , Mn 2+ , Ni 2+ , La 3+ and some positively charged organic compounds (hexamethonium and poly-lysine) when applied topically to the injured site abolished...
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