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In an effort to expand the spectrum of activity of the oxazolidinone class of antibacterial agents to include Gram-negative bacteria, a series of new carbon-carbon linked pyrazolylphenyl analogues has been prepared. The α-N-substituted methyl pyrazole (10α) in the C3-linked series exhibited very good Gram-positive activity with MICs =<0.5-1μg/mL and moderate Gram-negative activity with MICs=2-8μg/mL...
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