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Mucous membrane pemphigoid (MMP) is a rare, chronic and often aggressive subepidermal autoimmune blistering disease potentially affecting several mucous membranes with blisters and secondary erosions and scars. The pathogenesis of MMP is poorly understood, and the contribution of genetic predispositions, other than HLA class II allele variants to MMP, is unknown. The objective of this study is to...
Abstract: Proteases and their receptors have poorly understood roles in skin fibrosis and systemic scleroderma (SSc). We examined the role of protease‐activated receptors (PAR1 and PAR2) in the pathophysiology of human SSc and skin fibrosis. Immunohistochemistry showed that PAR1 immunoreactivity was positive in fibroblasts of SSc skin and healthy skin. PAR2 immunoreactivity was positive in SSc skin,...
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