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This work was designed to examine whether brain endomorphins (EM1 and EM2), the endogenous μ-opioid ligands, are involved in electroacupuncture (EA)-induced analgesia in the mice. C57BL/6J mice were given EA for 30 min and the effect of EA-induced analgesia was assessed by radiant heat tail flick latency (TFL). Intracerebroventricular (i.c.v.) injection of μ-opioid receptor antagonist D-Phe-Cys-Tyr-D-Tyr-Orn-Thr-Pen-Thr-NH...
This work was designed to elucidate the possible involvement of endogenous endomorphin-l (EM1) in analgesia induced by electroacupuncture of low or high frequencies. Taking radiant heat tail flick latency (TFL) as an indication of nociception, rats were subjected to intrathecal (i.t.) injection of 10 μl antiserum against EM1 (EM1-AS) or normal rabbit serum (NRS, as control) and then followed by 2...
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