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Abstract. The prevaleance of morbid obesity (body mass index of 35.0 or greater) is low in Japan (0.20.3%), and little systematic investigation of its cause in this population has been carried out. Leptin plays a central role in regulation of body weight; mice deficient in leptin develop marked obesity. We sought mutations in the leptin gene in 53 morbidly obese Japanese (maximum body mass index 3560)...
The prevaleance of morbid obesity (body mass index of 35.0 or greater) is low in Japan (0.2–0.3%), and little systematic investigation of its cause in this population has been carried out. Leptin plays a central role in regulation of body weight; mice deficient in leptin develop marked obesity. We sought mutations in the leptin gene in 53 morbidly obese Japanese (maximum body mass index 35–60) including...
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