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μ‐Opioid receptors (μ‐ORs) play a critical role in the modulation of pain and mediate the effects of the most powerful analgesic drugs. Despite extensive efforts, it remains insufficiently understood how μ‐ORs produce specific effects in living cells. We developed new fluorescent ligands based on the μ‐OR antagonist E‐p‐nitrocinnamoylamino‐dihydrocodeinone (CACO), that display high affinity, long...
Hochselektive fluoreszierende Liganden abgeleitet aus dem Schlafmohn, wurden von D. Calebiro, M. Decker et al. in ihrem Forschungsartikel auf S. 6014 entwickelt, um zu untersuchen, ob μ‐Opioidrezeptoren (μ‐ORs) Dimere auf der Plasmamembran bilden können. Die Verbindungen weisen eine lange Verweilzeit und hohe Affinität auf, und eine kleine Fraktion kurzlebiger Homodimere konnte mithilfe dieser chemischen...
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